Combined lysis of thrombus with ultrasound and systemic tissue plasminogen activator for emergent revascularization in acute ischemic stroke (CLOTBUST‐ER): design and methodology of a multinational phase 3 trial

ConclusionsSince intravenous recombinant tissue‐plasminogen‐activator remains the only medical therapy to reverse ischemic stroke applicable in the emergency department, our trial will determine if the additional use of transcranial ultrasound improves functional outcomes in patients with severe acute ischemic stroke (NCT#01098981).

Source: International Journal of Stroke - June 29, 2015 Category: Neurology Authors: Peter D. Schellinger, Andrei V. Alexandrov, Andrew D. Barreto, Andrew M. Demchuk, Georgios Tsivgoulis, Martin Kohrmann, John Alleman, Virginia Howard, George Howard, Anne W. Alexandrov, Gordon Brandt, Carlos A. Molina, Tags: Protocol Source Type: research