COMP promotes pancreatic fibrosis by activating pancreatic stellate cells through CD36-ERK/AKT signaling pathways
CONCLUSION: In conclusion, this study showed that COMP was up-regulated in CP fibrotic tissues and COMP induced the activation, proliferation and migration of PSCs through the CD36-ERK/AKT signaling pathway. COMP may be a potential therapeutic candidate for the treatment of CP. Interfering with the expression of COMP or the communication between COMP and CD36 on PSCs may be the next direction for therapeutic research.PMID:38479555 | DOI:10.1016/j.cellsig.2024.111135
Source: Cellular Signalling - Category: Cytology Authors: Yi Wang Hai-Tao Li Gang Liu Chuan-Shen Jiang Yan-Hong Ni Jing-Hui Zeng Xia Lin Qing-Yun Wang Da-Zhou Li Wen Wang Xiang-Peng Zeng Source Type: research