Chronic MK-801 administration provokes persistent deficits in social memory in the prairie vole (Microtus ochrogaster): a potential animal model for social deficits of schizophrenia

Behav Brain Res. 2024 Mar 11:114948. doi: 10.1016/j.bbr.2024.114948. Online ahead of print.ABSTRACTThe prairie vole (Microtus ochrogaster) is a rodent species that has been used extensively to study biological aspects of human social bonding. Nevertheless, this species has not been studied in the context of modeling social deficits characteristic of schizophrenia. Building on studies in rodents that show that sub-chronic administration of an NMDA receptor antagonist induces persistent behavioral and neurological characteristics of schizophrenia, we administered MK-801 (0.2mg/kg, daily, for 7 days) or physiological saline to young adult (45 days old) virgin male voles. At 69 days of age, we paired these males with virgin females. 24h later, we assessed the males' social investigation of each female across the first 5min of a three-hour preference test, and side-by-side contact with each female during the last hour of the test. Unlike saline-treated males, MK-801-treated males did not preferentially investigate the unfamiliar female, indicating a deficit in social memory. Although males of both groups preferentially spent time with their female partner, regression analysis revealed that deficits in social memory predicted lower partner preference in MK-801-treated males. We interpret these results in the context of recent studies of the natural history of the prairie vole as well as in the context of cognitive deficits in schizophrenia and propose that the social component of e...
Source: Behavioural Brain Research - Category: Neurology Authors: Source Type: research