Vascular ATGL-dependent lipolysis and the activation of cPLA < sub > 2 < /sub > -PGI < sub > 2 < /sub > pathway protect against postprandial endothelial dysfunction

In conclusion, vascular ATGL-cPLA2-PGI2 dependent pathway activated by lipid overload and linked to LDs formation in endothelium and smooth muscle cells has a vasoprotective role by counterbalancing detrimental effects of lipid overload on endothelial function.PMID:38467757 | DOI:10.1007/s00018-024-05167-6

Source: Cellular and Molecular Life Sciences : CMLS - March 12, 2024 Category: Cytology Authors: M Sternak M Stojak T Banasik A Kij A Bar M Z Pacia K Wojnar-Lason N Chorazy T Mohaissen B Marczyk I Czyzynska-Cichon Z Berkimbayeva A Mika S Chlopicki Source Type: research