Topological features of functional brain networks and subclinical impulsivity: an investigation in younger and older adults

Brain Struct Funct. 2024 Mar 6. doi: 10.1007/s00429-023-02745-5. Online ahead of print.ABSTRACTImpulsive traits (i.e., the tendency to act without forethought regardless of negative outcomes) are frequently found in healthy populations. When exposed to risk factors, individuals may develop debilitating disorders of impulse control (addiction, substance abuse, gambling) characterized by behavioral and cognitive deficits, eventually leading to huge socioeconomic costs. With the far-reaching aim of preventing the onset of impulsive disorders, it is relevant to investigate the topological organization of functional brain networks associated with impulsivity in sub-clinical populations. Taking advantage of the open-source LEMON dataset, we investigated the topological features of resting-state functional brain networks associated with impulsivity in younger (n = 146, age: 20-35) and older (n = 61, age: 59-77) individuals, using a graph-theoretical approach. Specifically, we computed indices of segregation and integration at the level of specific circuits and nodes known to be involved in impulsivity (frontal, limbic, and striatal networks). In younger individuals, results revealed that impulsivity was associated with a more widespread, less clustered and less efficient functional organization, at all levels of analyses and in all selected networks. Conversely, impulsivity in older individuals was associated with reduced integration and increased segregation of striatal regions. Sp...
Source: Brain Structure and Function - Category: Neuroscience Authors: Source Type: research