Hyperforin ameliorates neuroinflammation and white matter lesions by regulating microglial VEGFR < sub > 2 < /sub > /SRC pathway in vascular cognitive impairment mice

CONCLUSION: Hyperforin effectively modulated microglial M1 polarization and neuroinflammation by inhibiting the VEGFR2 /SRC signaling pathways, thereby ameliorating WMLs and cognitive impairment in VCI mice.PMID:38468126 | DOI:10.1111/cns.14666

Source: CNS Neuroscience and Therapeutics - March 12, 2024 Category: Neuroscience Authors: Xin Gao Jingjing Chen Ge Yin Yanqun Liu Zhengsheng Gu Rui Sun Xu Sun Xuehao Jiao Ling Wang Nuo Wang Yanbo Zhang Yuting Kan Xiaoying Bi Bingying Du Source Type: research