Interactions between skin-resident dendritic and Langerhans cells and pain-sensing neurons

Various immune cells in the skin contribute to its function as a first line of defence against infection/disease, while its dense innervation by pain-sensing sensory neurons protects the host from injury/damage signals. Dendritic cells (DCs) are a heterogeneous population of cells that link the innate immune response to the adaptive response by capturing, processing, and presenting antigens to promote T-cell differentiation and activation. DCs are abundant across peripheral tissues, including the skin, where they are found in the dermis and epidermis.
Source: Journal of Allergy and Clinical Immunology - Category: Allergy & Immunology Authors: Source Type: research