Novel strategies based on natural products and synthetic derivatives to overcome resistance in Mycobacterium tuberculosis

Eur J Med Chem. 2024 Feb 23;269:116268. doi: 10.1016/j.ejmech.2024.116268. Online ahead of print.ABSTRACTOne of the biggest health challenges of today's world is the emergence of antimicrobial resistance (AMR), which renders conventional therapeutics insufficient and urgently demands the generation of novel antimicrobial strategies. Mycobacterium tuberculosis (M. tuberculosis), the pathogen causing tuberculosis (TB), is among the most successful bacteria producing drug-resistant infections. The versatility of M. tuberculosis allows it to evade traditional anti-TB agents through various acquired and intrinsic mechanisms, rendering TB among the leading causes of infectious disease-related mortality. In this context, researchers worldwide focused on establishing novel approaches to address drug resistance in M. tuberculosis, developing diverse alternative treatments with varying effectiveness and in different testing phases. Overviewing the current progress, this paper aims to briefly present the mechanisms involved in M. tuberculosis drug-resistance, further reviewing in more detail the under-development antibiotics, nanotechnological approaches, and natural therapeutic solutions that promise to overcome current treatment limitations.PMID:38460268 | DOI:10.1016/j.ejmech.2024.116268
Source: European Journal of Medicinal Chemistry - Category: Chemistry Authors: Source Type: research