The Integration of Top-down and Bottom-up Inputs to the Striatal Cholinergic Interneurons

CONCLUSION: This study provides in vivo evidence that the multiphasic ChI response may require both top-down and bottom-up inputs. The findings suggest that the firing pattern of ChIs correlated to the iLFP might be a useful tool for estimating the degree of contribution of top-down and bottom-up inputs in regulating the firing activity of ChIs.PMID:38420787 | DOI:10.2174/1570159X22666231115151403

Source: Current Neuropharmacology - February 29, 2024 Category: Drugs & Pharmacology Authors: Yan-Feng Zhang John N J Reynolds Source Type: research