Efficacy and safety of levosimendan in patients with sepsis: a systematic review and network meta-analysis

Conclusion: The existing evidence suggests that levosimendan can significantly improve CI and lactate levels in patients with sepsis, and levosimendan at 0.1 µg/kg/min might be the optimal dose. Unfortunately, all interventions in this study failed to reduce the 28-day mortality.Systematic Review Registration:https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42023441220.
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research