Effect of the closed-loop hippocampal low-frequency stimulation on seizure severity, learning, and memory in pilocarpine epilepsy rat model

CONCLUSION: Applying closed-loop, low-frequency DBS at seizure onset reduced seizure severity and improved memory. In addition, the changes in power, coherence, and coupling of the LFP oscillations in the hippocampus and mPFC demonstrate low-frequency DBS efficacy as an antiepileptic treatment, returning LFPs to a seemingly non-seizure state in subjects that received DBS.PMID:38439573 | PMC:PMC10912795 | DOI:10.1111/cns.14656

Source: CNS Neuroscience and Therapeutics - March 5, 2024 Category: Neuroscience Authors: Meysam Zare Mahmoud Rezaei Milad Nazari Nastaran Kosarmadar Mona Faraz Victoria Barkley Amir Shojaei Mohammad Reza Raoufy Javad Mirnajafi-Zadeh Source Type: research