COVID-19 vaccination and infection status: a cross-sectional survey of patients with rheumatic diseases in China

AbstractTo evaluate the vaccination status and clinical practice of patients with rheumatic diseases (RD) during the COVID-19 pandemic in China and to explore the impact of vaccination on infection severity in patients with RD. A cross-sectional survey was conducted among RD patients in outpatient and inpatient settings of the Rheumatology and Immunology Department in our hospital. Participants ’ characteristics, vaccination status, COVID-19 infection status, and medication for acute COVID-19 were collected. A total of 749 valid surveys were included in the study. A total of 271 (36.2%) patients were not vaccinated, and 478 (63.8%) patients received at least one dose of COVID-19 vaccine. 83.3% of patients were vaccinated with inactivated vaccines. Several patients with RD experienced the disease flare (57, 11.9%) and some adverse reactions (31, 6.5%) after COVID-19 vaccination. The COVID-19 infection rate was 84.1% in our study, which was not reduced by vaccination. However, vaccin ated patients with RD showed decreased frequencies of pneumonia and hospitalization, compared with those of unvaccinated patients. Independent factors associated with hospitalization were COVID-19 vaccination (OR = 0.422, 95% CI 0.227–0.783), advanced age (OR = 1.070, 95% CI 1.046–1.095) , ILD (OR = 1.245, 95% CI 1.082–1.432), and glucocorticoid (OR = 4.977, 95% CI 2.326–10.647). Adverse reactions to vaccines and disease flare are not common in RD patients. Although COVID-...
Source: Rheumatology International - Category: Rheumatology Source Type: research