Pediatric Medullary Thyroid Carcinoma: Clinical Presentations and Long-term Outcomes in 144 Patients Over Six Decades

CONCLUSIONS: sMTC is primarily a RET-driven disease that represents 14% of childhood-onset MTC in this cohort. Pediatric sMTC patients are older, present with clinical disease at a more advanced TNM classification, and have more persistent disease at last follow up compared with hMTC, but these differences disappear when comparing those presenting clinically. Somatic molecular testing should be considered in sMTC patients who would benefit from systemic therapy.PMID:38441533 | DOI:10.1210/clinem/dgae133

Source: The Journal of Clinical Endocrinology and Metabolism - March 5, 2024 Category: Endocrinology Authors: Sarah G Hensley Mimi I Hu Roland L Bassett Anita K Ying Mark E Zafereo Nancy D Perrier Naifa L Busaidy Samuel M Hyde Elizabeth G Grubbs Steven G Waguespack Source Type: research