Cardiac Resolvin D2 ameliorates sepsis-induced cardiomyopathy via inhibiting Caspase-11/GSDMD dependent pyroptosis

CONCLUSION: These findings suggest that decreased cardiac RvD2 may involve in the pathogenesis of SICM. In addition, treatment with RvD2 represents a novel therapeutic strategy for SICM by inhibiting cardiomyocytes pyroptosis.PMID:38437927 | DOI:10.1016/j.freeradbiomed.2024.02.026

Source: Free Radical Biology and Medicine - March 4, 2024 Category: Biology Authors: Wen-Wu Zhang Shun-Shun Wang Yang-Dong Ding Xin-Yi Wu Jin-Ling Wei Ye Gao Sheng-Wei Jin Pu-Hong Zhang Source Type: research