Cancers, Vol. 16, Pages 1057: Glutamine Supplementation as an Anticancer Strategy: A Potential Therapeutic Alternative to the Convention

Cancers, Vol. 16, Pages 1057: Glutamine Supplementation as an Anticancer Strategy: A Potential Therapeutic Alternative to the Convention Cancers doi: 10.3390/cancers16051057 Authors: Hayato Muranaka Rasaq Akinsola Sandrine Billet Stephen J. Pandol Andrew E. Hendifar Neil A. Bhowmick Jun Gong Glutamine, a multifaceted nonessential/conditionally essential amino acid integral to cellular metabolism and immune function, holds pivotal importance in the landscape of cancer therapy. This review delves into the intricate dynamics surrounding both glutamine antagonism strategies and glutamine supplementation within the context of cancer treatment, emphasizing the critical role of glutamine metabolism in cancer progression and therapy. Glutamine antagonism, aiming to disrupt tumor growth by targeting critical metabolic pathways, is challenged by the adaptive nature of cancer cells and the complex metabolic microenvironment, potentially compromising its therapeutic efficacy. In contrast, glutamine supplementation supports immune function, improves gut integrity, alleviates treatment-related toxicities, and improves patient well-being. Moreover, recent studies highlighted its contributions to epigenetic regulation within cancer cells and its potential to bolster anti-cancer immune functions. However, glutamine implementation necessitates careful consideration of potential interactions with ongoing treatment regimens and the delicate equilibrium between supporting norm...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Review Source Type: research