Contemporary Diuretic Therapies for Acute Heart Failure, time for a Desalination-Guided Approach?

Simultaneous and fast implementation of four different classes of guideline directed medical therapy markedly improves symptoms as well as prognosis in chronic heart failure patients, with beneficial effects on outcome occurring within weeks.1 Loop diuretics have a class I recommendation in all ejection fraction classes to treat signs and symptoms of congestion, but robust clinical trial evidence to guide their use is sparse, which is reflected in a class IC (expert) guideline recommendation. Despite routine use of high dose loop diuretics, many patients are discharged with residual congestion which is a strong predictor of poor outcome.
Source: Journal of Cardiac Failure - Category: Cardiology Authors: Tags: JCF Ignite! Source Type: research