Myelodysplastic syndrome with IgG4 ‑related disease: A case report

Oncol Lett. 2024 Feb 20;27(4):166. doi: 10.3892/ol.2024.14299. eCollection 2024 Apr.ABSTRACTAt present, to the best of our knowledge, there are only a few case reports of IgG4-related disease (IgG4-RD) involving myelodysplastic syndrome (MDS), yet the incidence of MDS and IgG4-RD is increasing in middle-aged and elderly people. The present study presents a case of MDS combined with IgG4-RD admitted to Zhejiang Provincial Hospital of Chinese Medicine in September 2022. The (66-year-old; male) patient was admitted to the hospital due to hematopenia with an elevated IgG4 index. The diagnosis of MDS combined with IgG4-RD was confirmed after various exams, including pathological examination. The condition of the patient improved after 3 weeks of hormone therapy, with a significant increase in complete blood count compared with the pre-treatment period. MDS is a malignant hematological disorder with a high risk of conversion to leukemia, and IgG4-RD is a systemic immune-mediated disease with a poor prognosis often associated with malignancy. The present study presents and reviews the literature to better understand the coexistence of these two diseases.PMID:38426159 | PMC:PMC10902754 | DOI:10.3892/ol.2024.14299
Source: Oncology Letters - Category: Cancer & Oncology Authors: Source Type: research