GSE260450 The effect of high fat diet on mouse prostate development

Contributors : Sharkey Christina ; Xingbo Long ; Ra'ad Al-Faouri ; Douglas Strand ; Aria F Olumi ; Zongwei WangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusSteroid 5 α reductase 2 (SRD5A2) is the predominant enzyme responsible for prostatic development and growth. Despite the introduction of steroid 5α-reductase inhibitors (5ARI) for benign prostatic hyperplasia (BPH), the progression of LUTS is only slowed by 34% with 5ARI-response. Previous literature establ ishes link between obesity and BPH progression. We hypothesize that high fat diet is associated with prostate development.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research