MBNL1 Regulates Programmed Postnatal Switching Between Regenerative and Differentiated Cardiac States

CONCLUSIONS: Here, MBNL1 was identified as an essential regulator of cardiomyocyte differentiated states, their developmental switch from hyperplastic to hypertrophic growth, and their regenerative potential through controlling an entire maturation program by stabilizing adult myocyte mRNAs during postnatal development and throughout adulthood. Targeting loss of cardiomyocyte maturity and downregulation of cell cycle inhibitors through MBNL1 deletion was not sufficient to promote adult regeneration.PMID:38426339 | DOI:10.1161/CIRCULATIONAHA.123.066860

Source: Circulation - March 1, 2024 Category: Cardiology Authors: Logan R J Bailey Darrian Bugg Isabella M Reichardt C Dessir ée Ortaç Abigail Nagle Jagadambika Gunaje Amy Martinson Richard Johnson Michael J MacCoss Tomoya Sakamoto Daniel P Kelly Michael Regnier Jennifer M Davis Source Type: research