Monocytes Release Pro-Cathepsin D to Drive Blood-to-Brain Transcytosis in Diabetes

CONCLUSIONS: These findings uncover the novel role of circulatory pro-CTSD from monocytes in the pathogenesis of cerebral microvascular lesions in diabetes. The circulatory pro-CTSD is a potential target for the intervention of microvascular complications in diabetes.PMID:38420756 | DOI:10.1161/CIRCRESAHA.123.323622

Source: Circulation Research - February 29, 2024 Category: Cardiology Authors: Dan Zhao Zeng-Kang Huang Yu Liang Zhi-Jun Li Xue-Wei Zhang Kun-Hang Li Hao Wu Xu-Dong Zhang Chen-Sheng Li Dong An Xue Sun Ming-Xin An Jun-Xiu Shi Yi-Jun Bao Li Tian Di-Fei Wang An-Hua Wu Yu-Hua Chen Wei-Dong Zhao Source Type: research