Chemical Profiling and Enzyme Inhibitory Activities of Essential Oil Isolated from Pistacia Khinjuk Leaves: Insights On GC-MS Analysis and Skin Aging-Relevant Enzymes

This study aimed to investigate the GC-MS chemical composition of essential oil isolated from Pistaciakhinjuk leaves and its inhibitory properties against aging-relevant enzymes such a collagenase and elastase. The isolated oil showed predominance of β-cadinene (15.34%), γ-amorphene (8.50%), α-cadinol (8.14%), τ-cadinol (7.57%), (E)-β-caryophyllene (5.77%), α-pinene (4.70%), phytol (4.57%), α-muurolene (3.30%), (+)-epi-bicyclosesquiphellandrene (3.21%), and cubenene (3.16%). Further, it showed remarkable inhibitory activities against collagenase and elastase with IC50 values of 15.61±0.69 and 41.12±2.09 μg/mL, respectively compared to epigallocatechin gallate (IC50=29.52±1.3 μg/mL and 26.86±1.37 μg/mL). as a conclusion, the leaf oil is recommended for topical cosmetic preparations to retard skin aging symptoms such as wrinkles. However, the bioavailability assessment and toxicological profile should be considered in the future studies.PMID:38412297 | DOI:10.1002/cbdv.202302096
Source: Chemistry and Biodiversity - Category: Biochemistry Authors: Source Type: research