Understanding the systemic effects of intrapleural tPA and DNase by evaluating effects on coagulation

CONCLUSIONS: This is the first study to evaluate measurable changes in systemic coagulation after intrapleural tPA and DNase. Our data demonstrates no significant difference in coagulation after intrapleural tPA and DNase infusion, suggesting that there may not be clinically significant absorption.PMID:38410602 | PMC:PMC10894429 | DOI:10.21037/jtd-23-847

Source: Journal of Thoracic Disease - February 27, 2024 Category: Respiratory Medicine Authors: Thomas W Marston Kartikeya Rajdev Kaeli K Samson Daniel M Hershberger Source Type: research