Role of viable but non culturable cells in patients with cystic fibrosis in the era of highly effective modulator therapy

Cystic fibrosis (CF) is a genetic disease that results in the accumulation and the lack of clearance of dehydrated mucus, mostly in the respiratory system, and hence in bronchiectasis [1]. This thick mucus traps most inhaled bacteria and viruses in the airways, making patients more susceptible to infection. During the first years of life CF sputum cultures show the presence of Haemophilus influenzae and Staphylococcus aureus, presumed to be the source of the lung morbidity in children [2]. Meticulous daily management of lung infections combining airway clearance techniques together with prompt, aggressive antibiotic treatments are essential to prevent the progression of lung disease.

Source: Journal of Cystic Fibrosis - February 28, 2024 Category: Respiratory Medicine Authors: Natalia Cirilli, Valentina Schiavoni, Valentina Tagliabracci, Rosaria Gesuita, Luca Tiano, Benedetta Fabrizzi, Anastasia D'Antuono, Arianna Peruzzi, Nicholas Cedraro, Flavia Carle, Marco Moretti, Luigi Ferrante, Carla Vignaroli, Francesca Biavasco, Gianma Tags: Original Article Source Type: research