Basophils are important for development of allergic skin inflammation

Atopic dermatitis (AD) is the most common skin inflammation in infants and young children. It is characterized by intense itching, skin barrier defects, epidermal hyperplasia, dermal infiltration by T cells and eosinophils, and type 2 –dominated local immune response, evidenced by increased cutaneous expression of type 2 cytokines and eosinophilia. In addition, AD patients exhibit elevated levels of serum IgE and IgE antibodies to environmental and food allergens.1,2

Source: Journal of Allergy and Clinical Immunology - February 6, 2024 Category: Allergy & Immunology Authors: Juan-Manuel Leyva-Castillo, Daniela Vega-Mendoza, Maria Strakosha, Liwen Deng, Samantha Choi, Kensuke Miyake, Hajime Karasuyama, Isaac M. Chiu, Wanda Phipatanakul, Raif S. Geha Source Type: research