1-kestose blocks UVB-induced skin inflammation and promotes Type I procollagen synthesis via regulating MAPK/AP-1, NF- κB and TGF-β/Smad pathway

J Microbiol Biotechnol. 2024 Feb 22;35(5):1-10. doi: 10.4014/jmb.2311.11020. Online ahead of print.ABSTRACTSolar UVB irradiation cause skin photoaging by inducing the high expression of matrix metalloproteinase (MMPs) to inhibit the expression of Type1 procollagen synthesis. 1-kestose, a natural trisaccharide, has been indicated to show a cytoprotective role in UVB radiation-induced-HaCaT cells. However, few studies have confirmed the anti-aging effects. In the present study, we evaluated the anti-photoaging and pathological mechanism of 1-kestose using Human keratinocytes (HaCaT) cells. The results found that 1-kestose pretreatment remarkably reduced UVB-generated reactive oxygen species (ROS) accumulation in HaCaT cells. 1-kestose suppressed UVB radiation-induced MMPs expressions by blocking MAPK/AP-1 and NF-κB p65 translocation. 1-kestose pretreatment increased Type 1 procollagen gene expression levels by activating TGF-β/Smad signaling pathway. Taken together, our results demonstrate that 1-kestose may serve as a potent natural trisaccharide for inflammation and photoaging prevention.PMID:38379292 | DOI:10.4014/jmb.2311.11020
Source: Journal of Microbiology and Biotechnology - Category: Biotechnology Authors: Source Type: research