Reduced Monocyte and Neutrophil Infiltration and Activation by P-Selectin/CD62P Inhibition Enhances Thrombus Resolution

CONCLUSIONS: Inhibition of P-selectin-dependent activation of monocytes and neutrophils accelerates venous thrombosis resolution due to reduced infiltration and activation of innate immune cells at the site of thrombus formation, which prevents early thrombus stabilization and facilitates fibrinolysis.PMID:38385292 | DOI:10.1161/ATVBAHA.123.320016

Source: Arteriosclerosis, Thrombosis and Vascular Biology - February 22, 2024 Category: Cardiology Authors: Julia B Kral-Pointner Patrick Haider Petra L Szabo Manuel Salzmann Mira Brekalo Karl H Schneider Waltraud C Schrottmaier Christoph Kaun Sonja Bleichert Attila Kiss Romana Sickha Christian Hengstenberg Kurt Huber Christine Brostjan Helga Bergmeister Alice Source Type: research