Treating OCD: what to do when first-line therapies fail.

CONCLUSIONS: There is a paucity of research on how to manage OCD patients who fail to respond adequately to first line therapies. High-dose selective serotonin reuptake inhibitors (SSRIs) and clomipramine have good evidence-based data. Combinations of SSRIs have little support in clinical trials, but the combination of SSRIs and clomipramine can be helpful: careful clinical and cardiac monitoring is required. Certain adjunctive antipsychotics have a reasonable evidence base in OCD, but their use also needs to be weighed against the potential side effect burden. In patients with substantial generalised anxiety symptoms, clonazepam is worth considering. Of the other augmenting strategies, memantine and ondansetron appear useful in some cases, and are well tolerated. Topiramate might ameliorate compulsions to some degree, but it is less well tolerated. If all these strategies, along with expert psychological therapy, fail, careful consideration should be given to deep brain stimulation (DBS), which has an emerging evidence base and which can result in dramatic benefits for some individuals. For some patients, gamma radiosurgery might also still have a place. PMID: 26104775 [PubMed - as supplied by publisher]
Source: Australasian Psychiatry - Category: Psychiatry Authors: Tags: Australas Psychiatry Source Type: research

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ConclusionsRumination is known to be associated with poor prognosis in mental health. This study suggests that rumination is a maladaptive coping style associated not only with worry, distress and illness severity, but also with socioeconomic status. Also, rumination demonstrated a specific association with panic disorder.
Source: Journal of Psychiatric Research - Category: Psychiatry Source Type: research
This article is intended to provide an overview of the literature regarding mental disorders associated with polycystic ovary syndrome and to present own research on depression and sexual dysfunction in this group. PMID: 31760419 [PubMed - in process]
Source: Psychiatria Polska - Category: Psychiatry Tags: Psychiatr Pol Source Type: research
CONCLUSIONS: The research indicates that anxiety plays a significant role in the clinical picture of OCD and may reach a severity similar to that observed in GAD. The presence and severity of anxiety and somatization symptoms can be associated with the presence of cognitive impairments, which requires further investigation. PMID: 31760413 [PubMed - in process]
Source: Psychiatria Polska - Category: Psychiatry Tags: Psychiatr Pol Source Type: research
This report examined baseline emotional disorder symptoms, negative urgency (i.e., tendency to act impulsively in response to negative affect), and anhedonia (i.e., loss of interest in activities and decreased pleasure) as prospective predictors of increases in hedonic hunger in adolescents; associations between changes in emotional disturbance problems and hedonic hunger were also examined. Ninth-grade students (N = 2598) from high schools completed paper-and-pencil surveys at baseline and a 1-year follow-up. In a multivariable model controlling for the covariance of emotional problems, higher negative urgency, genera...
Source: Eating Behaviors - Category: Eating Disorders & Weight Management Authors: Tags: Eat Behav Source Type: research
"Cold" Cognitive Control and Attentional Symptoms in Anxiety: Perceptions Versus Performance. Behav Ther. 2019 Nov;50(6):1150-1163 Authors: Hallion LS, Tolin DF, Billingsley AL, Kusmierski SN, Diefenbach GJ Abstract Clinically significant anxiety is associated with an array of attentional symptoms (e.g., difficulty concentrating; unwanted thought) that are subjectively experienced as severe. However, neuropsychological findings are mixed with respect to the presence of cognitive deficits that can account for these symptoms. Contextualizing predictions from established clinical theories (e.g....
Source: Behavior Therapy - Category: Psychiatry & Psychology Authors: Tags: Behav Ther Source Type: research
Abstract Intolerance of uncertainty is a dispositional trait associated with a range of psychological disorders, but the influence of methodological factors on theses associations remains unknown. The first aim of this meta-analysis was to quantify the strengths of the association between IU and symptoms of generalised anxiety disorder, social anxiety disorder, panic disorder, agoraphobia, obsessive compulsive disorder, depression, and eating disorders. The second aim was to assess the influence of methodological factors on these relationships, including clinical (vs. non-clinical) status, age group, sex, IU measu...
Source: Clinical Psychology Review - Category: Psychiatry & Psychology Authors: Tags: Clin Psychol Rev Source Type: research
You're reading How to Prevent Your Anxiety from Rubbing Off On Your Child, originally posted on Pick the Brain | Motivation and Self Improvement. If you're enjoying this, please visit our site for more inspirational articles. Sometimes, it seems like our kids aren’t learning anything from us—but that’s simply not the case. Kids absorb all the information around them and learn by example. While that can be a good thing, it can also be a problem if you don’t want to pass on certain behaviors you’re modeling for them, like anxiety. If you’re struggling with anxiety, first remember that...
Source: PickTheBrain | Motivation and Self Improvement - Category: Consumer Health News Authors: Tags: depression family featured psychology self improvement Source Type: blogs
Publication date: Available online 27 August 2019Source: Pharmacology &TherapeuticsAuthor(s): Simone B. Sartori, Nicolas SingewaldAbstractCurrent medication for anxiety disorders is suboptimal in terms of efficiency and tolerability, highlighting the need for improved drug treatments. In this review an overview of drugs being studied in different phases of clinical trials for their potential in the treatment of fear-, anxiety- and trauma-related disorders is presented. One strategy followed in drug development is refining and improving compounds interacting with existing anxiolytic drug targets, such as serotonergic an...
Source: Pharmacology and Therapeutics - Category: Drugs & Pharmacology Source Type: research
Conclusions and discussionOur study showed significant associations between migraine headache and psychiatric disorders, as well as with role functioning and disability. The findings of our study emphasise the need for screening for psychiatric comorbidity among those with migraine and the development of appropriate interventions for this group.
Source: Social Psychiatry and Psychiatric Epidemiology - Category: Psychiatry Source Type: research
ConclusionsThe high treatment gap in the population is concerning and highlights the need to promote help-seeking and uptake of treatment. Given the unique demographic characteristics, i.e., those with higher education and employed were more likely not to seek treatment, targeted interventions in the educational and workplace settings should be implemented.
Source: Social Psychiatry and Psychiatric Epidemiology - Category: Psychiatry Source Type: research
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