Molecular portraits of patients with intrahepatic cholangiocarcinoma who diverge as rapid progressors or long survivors on chemotherapy

Conclusions
The RPLS signature could be a novel metric of chemotherapy outcome in iCCA. Further development and validation of this transcriptomic signature is warranted to develop precision chemotherapy strategies in these settings.

Source: Gut - February 23, 2024 Category: Gastroenterology Authors: O'Rourke, C. J., Salati, M., Rae, C., Carpino, G., Leslie, H., Pea, A., Prete, M. G., Bonetti, L. R., Amato, F., Montal, R., Upstill-Goddard, R., Nixon, C., Sanchon-Sanchez, P., Kunderfranco, P., Sia, D., Gaudio, E., Overi, D., Cascinu, S., Hogdall, D., P Tags: Open access, Gut Hepatology Source Type: research