Contractility defects hinder glycoprotein VI-mediated platelet activation and affect platelet functions beyond clot contraction

CONCLUSION: Our findings highlight the importance of both active contractile and passive crosslinking roles of myosin IIA in the platelet cytoskeleton. They support the hypothesis that highly contractile platelets are needed for hemostasis and further suggest a supportive role for myosin IIA in GPVI signaling.PMID:38379711 | PMC:PMC10877441 | DOI:10.1016/j.rpth.2024.102322

Source: Thrombosis and Haemostasis - February 21, 2024 Category: Hematology Authors: Martin Kenny Alice Y Pollitt Smita Patil Dishon W Hiebner Albert Smolenski Natalija Lakic Robert Fisher Reema Alsufyani Sebastian Lickert Viola Vogel Ingmar Schoen Source Type: research