A noncoding role of coding mRNA in monogenic olfactory receptor choice

Trends Neurosci. 2024 Feb 19:S0166-2236(24)00020-1. doi: 10.1016/j.tins.2024.02.004. Online ahead of print.ABSTRACTIn a recent study, Pourmorady and colleagues uncovered a noncoding role for olfactory receptor (OR)-coding mRNA in mediating nuclear architecture and singular OR choice. The OR mRNAs reinforce the prevailing enhancer hub and inhibit other competitors, facilitating transition from polygenic to singular OR expression.PMID:38378395 | DOI:10.1016/j.tins.2024.02.004

Source: Trends in Neurosciences - February 20, 2024 Category: Neuroscience Authors: Yue Hao Kang-Ying Qian Qian Li Source Type: research