Pregnancy-Associated Atypical Hemolytic Uremic Syndrome: A Case Report with MCP Gene Mutation and Successful Eculizumab Treatment

We present a case of a 25-year-old primigravida who experienced severe preeclampsia and HELLP syndrome followed by the development of complicated P-aHUS during the early postpartum period. The patient exhibited severe clinical manifestations, including hypertensive emergency, central nervous system involvement, renal impairment, and microangiopathic hemolytic anemia. Timely initiation of eculizumab therapy resulted in successful disease remission. Further genetic analysis revealed a likely rare pathogenic MCP gene variant. [...] Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents  |  Abstract  |  open access Full text

Source: American Journal of Perinatology Reports - February 21, 2024 Category: Perinatology & Neonatology Authors: Dom ínguez-Vargas, Alex Ari ño, Fanny Silva, Diana Gonz ález-Tórres, Henry J. Aroca-Martinez, Gustavo Egea, Eduardo Musso, Carlos G. Tags: Case Report Source Type: research