Applying Multiomics to Basosquamous Carcinoma

Basosquamous carcinoma (BSC) is a rare form of skin cancer defined by combined phenotypes of 2 common skin cancers: basal cell carcinoma (BCC) and cutaneous squamous cell carcinoma (cSCC). The heterogeneity of BSC provides tumors an intrinsic resistance to drugs that only target 1 phenotype, making standard therapy ineffective (Zelin et  al, 2022). Jussila et al (20231) utilize single-cell transcriptomics, spatial transcriptomics, and whole-exome sequencing to interrogate and spatially map phenotypic differences in a drug-resistant tumor from a patient with Gorlin syndrome.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Commentary Source Type: research