Mimicking Clinical Rejection Patterns in a Rat Osteomyocutaneous Flap Model of Vascularized Composite Allotransplantation

We present a rat osteomyocutaneous flap model using titrated tacrolimus administration that mimics the graft rejection patterns in our clinical hand transplant program. Comparison of outcomes in these models support a role for ischemia reperfusion injury (IRI) and microvascular changes in CR of skin and large-vessel vasculopathy.

Source: Journal of Surgical Research - November 16, 2023 Category: Surgery Authors: Jason E. Beare, Yoram Fleissig, Natia Q. Kelm, Robert M. Reed, Amanda J. LeBlanc, James B. Hoying, Christina L. Kaufman Tags: Transplantation and Immunology Source Type: research