Effects of levothyroxine treatment on fertility and pregnancy outcomes in subclinical hypothyroidism: a systematic review and meta-analysis of randomized controlled trials

CONCLUSIONS: Pre-conceptional levothyroxine treatment does not improve fertility or decrease the incidence of miscarriages. However, further well-designed studies are needed for pre-conceptional treatment, especially in TSH >4.0 mU/L. Levothyroxine treatment during pregnancy had a positive effect on preterm birth; nevertheless, this was only applicable to subclinical hypothyroidism with TSH >4.0 mU/L.PMID:38368537 | DOI:10.1089/thy.2023.0546

Source: Thyroid : official journal of the American Thyroid Association - February 18, 2024 Category: Endocrinology Authors: Akiko Sankoda Hitomi Suzuki Misa Imaizumi Ai Yoshihara Sakiko Kobayashi Miyuki Katai Katsuhiko Hamada Yoh Hidaka Aya Yoshihara Hannah Nakamura Sumihisa Kubota Maiko Kakita-Kobayashi Akira Iwase Takashi Sugiyama Erika Ota Naoko Arata Source Type: research