New mechanisms: From lactate to lactylation to rescue heart failure

Biosci Trends. 2024 Feb 8. doi: 10.5582/bst.2024.01000. Online ahead of print.ABSTRACTLactylation of α-myosin heavy chain (α-MHC) has recently been reported to preserve sarcomeric structure and function and attenuate the development of heart failure. Specifically, lactylation enhanced the interaction of α-MHC with the sarcomeric protein Titin, thereby maintaining normal sarcomeric structure and myocardial contractile function. Furthermore, the administration of lactate or inhibition of lactate efflux potentially treats heart failure by restoring lactylation of α-MHC and the interaction of α-MHC with Titin. This finding highlights the significant role of α-MHC lactylation in myocardial diseases and presents a new therapeutic target for the treatment of heart failure.PMID:38325822 | DOI:10.5582/bst.2024.01000
Source: BioScience Trends - Category: Biomedical Science Authors: Source Type: research