Exercise mean PAP to CO relationship: An insightful endpoint for testing therapeutic interventions in heart failure

Patients with heart failure (HF) complaint symptoms during effort whose origin is multifactorial but predominantly involve the maladaptive response of the right heart to the increased load. Occurrence of exercise-induced pulmonary hypertension (EiPH) [1,2] that may often yield to a “disproportionate” extent has emerged as quite common in HF [3,4]. The interest for EiPH and associated latent pulmonary vascular disease (PVD) has remarkably increased in the last decade with a number of measures of pulmonary hemodynamics, either invasively determined [4]or derived by imaging t echniques [3,5] that have received attention in the functional assessment of a broad range of cardiac and pulmonary vascular conditions documenting causality with exercise intolerance, dyspnea sensation and ventilation inefficiency [6].
Source: International Journal of Cardiology - Category: Cardiology Authors: Source Type: research