Gut Instincts: Unveiling the connection between gut microbiota and Alzheimer ’s disease

Alzheimer's disease (AD) is a neurodegenerative disorder marked by neuroinflammation and gradual cognitive decline. Recent research has revealed that the gut microbiota (GM) plays an important role in the pathogenesis of AD through the microbiota-gut-brain axis. However, the mechanism by which GM and microbial metabolites alter brain function is not clearly understood. GM dysbiosis increases the permeability of the intestine, alters the blood-brain barrier permeability, and elevates proinflammatory mediators causing neurodegeneration.
Source: Clinical Nutrition ESPEN - Category: Nutrition Authors: Tags: Narrative Review Source Type: research