Regulatory landscape of enhancer-mediated transcriptional activation

Trends Cell Biol. 2024 Feb 13:S0962-8924(24)00020-5. doi: 10.1016/j.tcb.2024.01.008. Online ahead of print.ABSTRACTEnhancers are noncoding regulatory elements that instruct spatial and temporal specificity of gene transcription in response to a variety of intrinsic and extrinsic signals during development. Although it has long been postulated that enhancers physically interact with target promoters through the formation of stable loops, recent studies have changed this static view: sequence-specific transcription factors (TFs) and coactivators are dynamically recruited to enhancers and assemble so-called transcription hubs. Dynamic assembly of transcription hubs appears to serve as a key scaffold to integrate regulatory information encoded by surrounding genome and biophysical properties of transcription machineries. In this review, we outline emerging new models of transcriptional regulation by enhancers and discuss future perspectives.PMID:38355349 | DOI:10.1016/j.tcb.2024.01.008

Source: Trends in Cell Biology - February 14, 2024 Category: Cytology Authors: Koji Kawasaki Takashi Fukaya Source Type: research