Deletion of Exoc7, but not Exoc3, in male germ cells causes severe spermatogenesis failure with spermatocyte aggregation in mice

In this study, we found that exocyst factor EXOC3 (SEC6) was not required for spermatogenesis, but depletion of EXOC7 (EXO70) led to severe spermatogenesis defects. In addition to being a component of the exocyst complex, EXOC1 has other functions. Notably, male germ cell-specific Exoc7 cKO and Exoc1 cKO mice exhibited phenotypic similarities, suggesting the importance of the exocyst complex for spermatogenesis. The results of this study will contribute to further understanding of spermatogenesis from the aspect of vesicular trafficking.PMID:38325858 | DOI:10.1538/expanim.23-0171

Source: Experimental Animals - February 7, 2024 Category: Research Authors: Natsuki Mikami Chi Lieu Kim Nguyen Yuki Osawa Kanako Kato Miyuki Ishida Yoko Tanimoto Kento Morimoto Kazuya Murata Woojin Kang Funihiro Sugiyama Masatsugu Ema Satoru Takahasi Seiya Mizuno Source Type: research