High concordance of molecular subtyping between pre-surgical biopsy and surgical resection specimen (matched-pair analysis) in patients with vulvar squamous cell carcinoma using p16- and p53-immunostaining

CONCLUSIONS: Compared to the final resections specimen, the three-tiered molecular classification of VSCC can be determined on pre-surgical biopsies with a high accuracy rate. This enables more precise surgical planning, prediction of the response to (chemo) radiation, selection of targeted therapies and planning of the optimal follow-up strategy for patients in the age of personalised medicine.PMID:38342005 | DOI:10.1016/j.ygyno.2024.02.001

Source: Gynecologic Oncology - February 11, 2024 Category: Cancer & Oncology Authors: Anne Kathrin H öhn Mirjam Forberger Mona Alfaraidi C Blake Gilks Christine Elisabeth Brambs Michael H öckel Lynn Hoang Naveena Singh Lars-Christian Horn Source Type: research