2-Phenylcyclopropylmethylamine (PCPMA) as a privileged scaffold for central nervous system drug design

Bioorg Med Chem Lett. 2024 Feb 13:129654. doi: 10.1016/j.bmcl.2024.129654. Online ahead of print.ABSTRACTThe use of privileged scaffolds in medicinal chemistry is an effective way to accelerate the drug discovery process, especially at the hit/lead optimization stage. 2-Phenylcyclopropylmethylamine (PCPMA) is a less commonly used chemical scaffold in medicinal chemistry, but many PCPMA-containing compounds exert therapeutic effects for various diseases, in particular central nervous system (CNS) diseases such as depression, schizophrenia, sleep disorder, and Parkinson's disease. The backbone of the PCPMA scaffold enables a unique structure of an amino group linked to a benzene ring through an alkyl linker, making it a useful template for the design of bioactive compounds especially for CNS drug targets including aminergic GPCRs and transporters. This review summarizes the medicinal chemistry studies of PCPMA-containing drugs and drug-like molecules, their mechanisms of action, and biological activities. We conclude that PCPMA is a unique and useful privileged scaffold for CNS drug design.PMID:38360418 | DOI:10.1016/j.bmcl.2024.129654
Source: Bioorganic and Medicinal Chemistry Letters - Category: Chemistry Authors: Source Type: research