Synergic actions of botulinum neurotoxin A and oxaliplatin on colorectal tumour cell death through the upregulation of TRPM2 channel-mediated oxidative stress

In conclusion, by increasing the susceptibility of HT29 tumour cells to oxidative stress and apoptosis, the combined administration of BoNT and OXA via the targeting of TRPM2 may offer a different approach to kill the tumour cells.PMID:38350599 | DOI:10.1111/1440-1681.13844
Source: Clinical Colorectal Cancer - Category: Cancer & Oncology Authors: Source Type: research