Effect of Tyrosine Kinase Inhibitor Therapy on Estimated Glomerular Filtration Rate in Patients with Chronic Myeloid Leukemia

CONCLUSION: Imatinib could result in a decline in eGFR which was clinically similar to early-stage CKD patients. We did not observe significant kidney function deterioration in patients receiving 2GTKIs including dasatinib and nilotinib. We recommend close renal function monitoring in patients receiving imatinib, especially for elderly patients with lower baseline eGFR and hypertension.PMID:38281820 | DOI:10.1016/j.clml.2023.12.004

Source: Clinical Lymphoma and Myeloma - January 28, 2024 Category: Cancer & Oncology Authors: Özge Sönmez Nurg ül Özgür Yurttaş İlker İhtiyaroğlu Halil Mete Çakır Zeynep Atl ı Tu ğrul Elverdi Ay şe Salihoğlu Nurhan Seyahi Muhlis Cem Ar Şeniz Öngören Zafer Ba şlar Teoman Soysal Ahmet Emre E şkazan Source Type: research