SARS-CoV-2 specific antibody response after an mRNA vaccine as the third dose: Homologous versus heterologous boost

In conclusion, waning immunity after inactivated vaccine can be recovered by BNT162b2 heterologous boost regardless of the age of recipients, and both boost strategies induced potent humoral immune response and protection against severe COVID-19 during the Omicron wave. However, as the observed incidence of breakthrough infections was higher in the homologous group, although non-significant, this finding could indicate an advantage of heterologous approach.PMID:38342717 | DOI:10.1016/j.vaccine.2024.01.085

Source: Vaccine - February 11, 2024 Category: Allergy & Immunology Authors: Olivera Lijeski ć Neda Bauman Milo š Marković Jelena Srbljanovi ć Branko Bobi ć Đorđe Zlatković Tijana Štajner Source Type: research