The HIF-1 α/PKM2 Feedback Loop in Relation to EGFR Mutational Status in Lung Adenocarcinoma

CONCLUSION: Different expression and clinical features of HIF-1α/PKM2 feedback loop was existed between LUAD and normal lung tissues, especially in EGFR mutational tumors, supporting the relationship between EGFR mutation and the key related proteins of aerobic glycolysis (HIF-1α and PKM2) in lung adenocarcinomas.PMID:38224012 | DOI:10.1080/08941939.2023.2301081
Source: Journal of Investigative Surgery - Category: Surgery Authors: Source Type: research