The alteration of mucosal bile acid profile is associated with nerve growth factor expression in mast cells and bowel symptoms in diarrhea-predominant irritable bowel syndrome

In conclusion, IBS-D patients showed an altered BA profile in the colonic mucosa. Approximately 20% of them exhibit elevated mucosal BA content, which may be associated with MMC-derived NGF signaling and bowel symptoms.PMID:38290436 | DOI:10.1093/cei/uxae006
Source: Clinical and Developmental Immunology - Category: Allergy & Immunology Authors: Source Type: research