DGAT2 inhibition blocks SREBP-1 cleavage and improves hepatic steatosis by increasing phosphatidylethanolamine in the ER

This study reveals a new mechanism that regulates SREBP-1 activation and lipogenesis that is independent of sterols and SREBP-2 in liver.PMID:38340721 | DOI:10.1016/j.cmet.2024.01.011

Source: Cell Metabolism - February 10, 2024 Category: Cytology Authors: Shunxing Rong Mingfeng Xia Goncalo Vale Simeng Wang Chai-Wan Kim Shili Li Jeffrey G McDonald Arun Radhakrishnan Jay D Horton Source Type: research