LAIR1-mediated resistance of hepatocellular carcinoma cells to T cells through a GSK-3 β/β-catenin/MYC/PD-L1 pathway

CONCLUSION: LAIR1 increased PD-L1 expression through the GSK-3β/β-catenin/MYC/PD-L1 pathway and promoted immune evasion of HCC cells. Targeted inhibition of LAIR1 helped to enhance the immune killing effect of CD8+ T cells in HCC.PMID:38199599 | DOI:10.1016/j.cellsig.2024.111039

Source: Cellular Signalling - January 10, 2024 Category: Cytology Authors: Banglun Pan Xiaoling Ke Jiacheng Qiu Dongjie Ye Zhu Zhang Xiaoxia Zhang Yue Luo Yuxin Yao Xiaoxuan Wu Xiaoqian Wang Nanhong Tang Source Type: research