Fluid-solid coupling numerical simulation of entire rat caudal vertebrae under dynamic loading

In this study, a fluid-solid coupling model of the entire vertebral bone was established based on micro-CT images obtained from rat tail vertebrae subjected to tensile loading experiments. The flow characteristics of bone marrow and the mechanical response of osteocytes in different regions under physiological loading were investigated. The results revealed a U-shaped distribution of wall fluid shear stress (FSS) along the longitudinal axis in trabecular bone, with higher FSS regions exhibiting greater mechanical stimulation on osteocytes. These findings elucidate a positive correlation between the mechanical microenvironment among osteocytes, osteoblasts, and osteoclasts, providing potential strategies for the prevention and treatment of bone diseases.PMID:38231258 | DOI:10.1080/10255842.2024.2304281
Source: Computer Methods in Biomechanics and Biomedical Engineering - Category: Biomedical Engineering Authors: Source Type: research