Pasteurella multocida strains of a novel capsular serotype and lethal to Marmota himalayana on Qinghai-Tibet plateau in China
Int J Med Microbiol. 2024 Jan 5;314:151597. doi: 10.1016/j.ijmm.2024.151597. Online ahead of print.ABSTRACTPasteurella multocida is a zoonotic pathogen causing serious diseases in humans and animals. Here, we report P. multocida from wildlife on China's Qinghai-Tibet plateau with a novel capsular serotype, forming a single branch on the core-genome phylogenetic tree: four strains isolated from dead Himalayan marmot (Marmota himalayana) and one genome assembled from metagenomic sequencing of a dead Woolly hare (Lepus oiostolus). Four of the strains were identified as subspecies multocida and one was septica. The mouse model showed that the challenge strain killed mice within 24 h at an infectious dose of less than 300 bacteria. The short disease course is comparable to septicemic plague: the host has died before more severe pathological changes could take place. Though pathological changes were relatively mild, cytokine storm was obvious with a significant rise of IL-12p70, IL-6, TNF-αand IL-10 (P < 0.05). Our findings suggested P. multocida is a lethal pathogen for wildlife on Qinghai-Tibet plateau, in addition to Yersinia pestis. Individuals residing within the M. himalayana plague focus are at risk for P. multocida infection, and public health warnings are necessitated.PMID:38217947 | DOI:10.1016/j.ijmm.2024.151597
Source: International Journal of Medical Microbiology - Category: Microbiology Authors: Ran Duan Dongyue Lyu Shuai Qin Junrong Liang Wenpeng Gu Qun Duan Weiwei Wu Deming Tang Haonan Han Xiaojin Zheng Jinxiao Xi Asaiti Bukai Xinmin Lu Peng Zhang Dan Zhang Meng Xiao Huaiqi Jing Xin Wang Source Type: research
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